Physiologic Insulin Resensitization (PIR®): A Promising Adjunctive Approach to Addressing Insulin Resistance and Metabolic Dysfunction (Copy)

As a family nurse practitioner with 30 years of experience in taking care of patients wholistically, the last couple of decades I have truly watched metabolic disorders that were once minimized or undertreated now identify as cardiometabolic crisis. Metabolic dysfunction is now prevalent in our pediatric population and is worsening throughout the lifespan. From PCOS in our young women to obesity, neuropathy, fatty liver, kidney disease, heart disease, and advanced diabetes, the United States reports almost half of its citizens now have metabolic syndrome.

Like many providers, I entered healthcare wanting to do more than manage health symptoms. I wanted to truly understand people and fix their problems. I wanted to investigate like Nancy Drew until I found the root cause- what in their environment was continuously exposing them to illness or chronic disease. How did their habits and family contribute? It’s the nursing model.

There’s a paradigm shift happening in healthcare right now. You can see it across social media, government initiatives, online communities, and in patients moving toward more collaborative care. The substantial growth of functional and integrative approaches, focusing on root causes, along with the explosion of AI and new technology, has been nothing short of transformative. With our ability now to truly fix problems and our open-mindedness to explore all options, we need to make metabolic disease our number one priority.

What Is Insulin Resistance?

Traditional diabetes care as one metabolic disease in particular has focused heavily on lowering blood glucose with medications, treating symptoms along with recommending healthy lifestyle changes. This treatment approach often leaves one of the main root causes— insulin resistance — untouched. So, let me simply explain here what insulin resistance is and how it happens.

In healthy people, the pancreas releases insulin in rhythmic pulses every few minutes often in response to the presence of glucose. These peaks and troughs are what insulin receptors on every cell recognize. The peaks drive glucose uptake into the cell. The troughs let the receptors reset and regain sensitivity. Over seventy-five percent of our insulin is delivered in these discrete bursts, not as a constant drip. This is how specific cells in the body receive nutrients and energy to serve their purpose.

With insulin resistance found in type 2 diabetes, this elegant rhythmic pattern is lost. Chronic high insulin flattens the pulses, receptors downregulate, and cells become blind to the signal. The result is elevated circulating glucose and insulin with nowhere to go, leading to pancreatic beta-cell stress, inflammation, and the cascade of complications we are experiencing in metabolic patients.

With its remarkable lifesaving discovery in 1922, insulin itself is not the problem, our delivery of it is. We perhaps dose too much, and perhaps too often, making receptor sites deaf to the signal. The same is happening in our broader population; we eat too much, too often, and with oversized portions. Our pancreases are constantly overworking and over-responding to glucose, once again making the receptor sites deaf to the signal. The diabetic patient from 20 years ago looks very different today. It could be any of us at any age. We have created this through our lifestyle and eating habits.

Enter Physiologic Insulin Resensitization

One promising treatment modality is reported to address this root cause: Physiologic Insulin Resensitization®, or PIR®. It's a multi-patented, physician-directed, intravenous insulin infusion process that is monitored and aims to focus on insulin sensitivity by reducing insulin resistance. Results reported in peer-reviewed medical journal articles indicate that it can restore the body's natural insulin signaling patterns. This can improve glucose uptake at the cell’s receptor site.

PIR® uses an FDA-approved external infusion device with proprietary software- that delivers precise, patient-specific micro-boluses of insulin intravenously in a rhythmic, pattern that resembles the body's natural pulses. The goal is to re-sensitize insulin receptors, improve glucose transport into cells, support mitochondrial energy production, and reduce the patient’s metabolic burden. PIR simply is being more strategic with the pharmacotherapy already FDA approved.

PIR is always used alongside standard medical care, nutrition and eating habits, lifestyle changes, and ongoing provider oversight — never as a replacement or a cure.

Growing recent observational data and small studies support this approach. A 2022 review in the International Journal of Molecular Sciences outlined the physiologic rationale. Retrospective observations have shown improvements in HgbA1C, neuropathy symptoms, medication needs, and even lower overall treatment costs in patients with diabetes and chronic kidney disease. With new patients started in 2026, we already are seeing better energy, reduced neuropathic pain, stabilization of kidney markers, and signs of improved skin health due to the possible facilitating of nutrients to the tissue.

Implementing PIR®

Well Cell Global is the biotech company responsible for the internationally patented PIR® treatment and is working diligently to perfect the technology and improve its research-based approach. Triad Global Health Solutions is assisting in creating a model of success that can be replicated across healthcare settings. Triad helps with the implementation of PIR into clinics and hospitals, bridging technology with real-world clinical systems. In 2025 I joined Triad because I believed I could speak to each area of the implementation components of PIR in the clinic and hospital environment from a provider and business perspective. With my partner, Amanda Shahan, and the rest of the team, we are able to create consistent, compliant and complementary protocols, staff education, and community encouragement, as well as the introduction of other ancillaries that contribute to measurable research and patient care. With this new way of implementing PIR, critical access hospitals and private clinics contribute real-world data to help advance science and support the next phase of FDA's evaluation for possible broader indications. It’s an exciting time for the technology and facilities who offer this treatment.

Metabolic wellness is never one-size-fits-all. PIR isn't a magic bullet, but when thoughtfully added it gives us a physiologic tool to move beyond symptom management and towards restoring cellular health and vitality.

I am optimistic about the future of metabolic care and committed to sharing transparent, compliant information so patients can make informed decisions. PIR is one I am prioritizing as a possible breakthrough treatment in my practice and have decided to pursue its advancement as well as other medications and lifestyle modifications. If you have questions about PIR or would like to discuss your metabolic health goals, I invite you to reach out!

Questions About PIR® Please Email:

jonna@triadglobalhealthsolutions.com or amanda@triadglobalhealthsolutions.com

Research Articles

WELL CELL GLOBAL RESEARCH ARTICLES